GYRA GENE PRODUCT Meaning and
Definition
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The "gyrA gene product" is a term used in the field of molecular biology and genetics to refer to a specific protein that is encoded by the gyrA gene. The gyrA gene is a specific gene found in many bacteria and is responsible for producing the protein known as DNA gyrase A.
DNA gyrase is an essential enzyme involved in the replication and maintenance of bacterial DNA. It plays a crucial role in DNA supercoiling, which is the process of twisting the DNA molecule on itself to compact it and allow for efficient packaging within the bacterial cell. This activity is important for many cellular processes, including DNA replication, transcription, and recombination.
The gyrA gene product, also commonly referred to as Gyrase A or GyrA, is one of the two subunits that make up the DNA gyrase enzyme, the other being GyrB. GyrA functions by introducing negative supercoils into the DNA molecule or by relaxing the positive supercoils. This dynamic regulation of supercoiling is crucial for maintaining the structural integrity of the bacterial chromosome.
The gyrA gene has gained considerable attention in the field of antibacterial drug discovery, as mutations in this gene can confer resistance to many widely used classes of antibiotics, such as fluoroquinolones. Understanding the structure and function of the gyrA gene product is, therefore, crucial for the development of new therapeutic strategies to combat bacterial infections.
Common Misspellings for GYRA GENE PRODUCT
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