The spelling of the word "Guisewite" is a challenge for many due to its unusual combination of letters. The correct pronunciation is /ɡaɪs.waɪt/, with the stress on the first syllable. The "gui" is pronounced as "guy," while the "sewite" is pronounced as "site." "Guisewite" is a surname of German origin, and its spelling may seem odd to English speakers because it uses two vowel combinations in one word. However, once you master the correct pronunciation, it's a memorable and distinctive name.