GUANOSINETRIPHOSPHATASE LINKED ELONGATION FACTORS Meaning and
Definition
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Guanosinetriphosphatase Linked Elongation Factors (GTPases) are a group of proteins that play a crucial role in the process of protein synthesis, specifically during the elongation phase. These proteins are essential for the accurate and efficient elongation of polypeptide chains during translation, which is a fundamental process in all living organisms.
GTPases are enzymes that hydrolyze guanosine triphosphate (GTP), converting it into guanosine diphosphate (GDP) and inorganic phosphate (Pi). They act as molecular switches, cycling between an active GTP-bound form and an inactive GDP-bound form. The binding and hydrolysis of GTP regulate the interactions and activities of GTPases.
Linked to elongation factors, GTPases stimulate ribosomes to move along the mRNA template during the elongation process. They facilitate the proper positioning of aminoacyl-tRNA on the ribosome, ensuring the accurate addition of amino acids to the growing polypeptide chain. GTPases also aid in ribosome recycling and the termination of translation.
The regulation of GTPases is critical for maintaining the integrity and fidelity of protein synthesis. They are regulated by various factors, including GTPase-activating proteins (GAPs) that enhance GTP hydrolysis and guanine nucleotide exchange factors (GEFs) that facilitate the exchange of GDP for GTP. Dysfunction or mutations in GTPases can lead to impaired protein synthesis, resulting in developmental disorders, neurodegenerative diseases, or cancer.
Common Misspellings for GUANOSINETRIPHOSPHATASE LINKED ELONGATION FACTORS
- fuanosinetriphosphatase linked elongation factors
- vuanosinetriphosphatase linked elongation factors
- buanosinetriphosphatase linked elongation factors
- huanosinetriphosphatase linked elongation factors
- yuanosinetriphosphatase linked elongation factors
- tuanosinetriphosphatase linked elongation factors
- gyanosinetriphosphatase linked elongation factors
- ghanosinetriphosphatase linked elongation factors
- gjanosinetriphosphatase linked elongation factors
- gianosinetriphosphatase linked elongation factors
- g8anosinetriphosphatase linked elongation factors
- g7anosinetriphosphatase linked elongation factors
- guznosinetriphosphatase linked elongation factors
- gusnosinetriphosphatase linked elongation factors
- guwnosinetriphosphatase linked elongation factors
- guqnosinetriphosphatase linked elongation factors
- guabosinetriphosphatase linked elongation factors
- guamosinetriphosphatase linked elongation factors
- guajosinetriphosphatase linked elongation factors
- guahosinetriphosphatase linked elongation factors
