GTP BINDING PROTEIN BETA SUBUNIT Meaning and
Definition
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The GTP binding protein beta subunit, also known as Gβ, is a component of heterotrimeric G proteins found in eukaryotes. It serves as one of the subunits that make up the beta-gamma dimer within the G protein complex, along with the GTP binding protein alpha subunit.
This protein functions as a molecular switch, transmitting signals from G protein-coupled receptors (GPCRs) to intracellular effector molecules. GPCRs are membrane receptors that play a crucial role in signal transduction across the plasma membrane. Upon activation by an extracellular ligand, the GPCR undergoes a conformational change that enables it to activate the associated G protein complex.
The GTP binding protein beta subunit, together with the alpha subunit, facilitates the activation of downstream effectors by exchanging bound GDP (guanosine diphosphate) for GTP (guanosine triphosphate). This nucleotide exchange induces a conformational change, leading to the dissociation of the G protein complex into its active subunits. The GTP-bound Gβγ dimer then interacts with and modulates the activity of various effector molecules, such as ion channels, enzymes, and transporters.
Furthermore, the GTP binding protein beta subunit also plays a crucial role in regulating the duration and strength of G protein-mediated signaling by promoting the hydrolysis of bound GTP to GDP. This hydrolysis renders the Gβγ dimer inactive, allowing it to reassociate with the G protein alpha subunit, forming an inactive heterotrimeric complex ready for another signaling cycle.
Common Misspellings for GTP BINDING PROTEIN BETA SUBUNIT
- ftp binding protein beta subunit
- vtp binding protein beta subunit
- btp binding protein beta subunit
- htp binding protein beta subunit
- ytp binding protein beta subunit
- ttp binding protein beta subunit
- grp binding protein beta subunit
- gfp binding protein beta subunit
- ggp binding protein beta subunit
- gyp binding protein beta subunit
- g6p binding protein beta subunit
- g5p binding protein beta subunit
- gto binding protein beta subunit
- gtl binding protein beta subunit
- gt- binding protein beta subunit
- gt0 binding protein beta subunit
- gtp vinding protein beta subunit
- gtp ninding protein beta subunit
- gtp hinding protein beta subunit
- gtp ginding protein beta subunit
