GRAMICIDIN DUBOS Meaning and
Definition
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Gramicidin Dubos is a naturally occurring antibiotic that belongs to the class of peptide antibiotics known as gramicidins. It is derived from the soil bacterium Bacillus brevis and was first isolated and studied by the French-born American microbiologist René Dubos in the 1930s.
Gramicidin Dubos is characterized by its ability to disrupt the integrity of bacterial cell membranes by forming ion channels. These ion channels allow for the unregulated flow of ions, particularly monovalent cations, such as sodium (Na+) and potassium (K+), across the bacterial cell membrane. This disruption ultimately leads to the death of the bacteria.
The unique mechanism of action of Gramicidin Dubos makes it an effective antibiotic against a wide range of gram-positive bacteria. It is particularly active against bacteria such as Staphylococcus and Streptococcus species. However, it is not effective against gram-negative bacteria due to the presence of a lipopolysaccharide layer in their cell membranes that inhibits the penetration of Gramicidin Dubos.
Due to its narrow spectrum of activity and potential toxicity, Gramicidin Dubos is primarily used in topical applications, such as in ointments and creams, to treat localized bacterial infections. Its limited systemic absorption also reduces the risk of adverse effects in patients.
In summary, Gramicidin Dubos is a naturally occurring peptide antibiotic that disrupts bacterial cell membranes and is primarily used in topical applications for the treatment of gram-positive bacterial infections.
Common Misspellings for GRAMICIDIN DUBOS
- framicidin dubos
- vramicidin dubos
- bramicidin dubos
- hramicidin dubos
- yramicidin dubos
- tramicidin dubos
- geamicidin dubos
- gdamicidin dubos
- gfamicidin dubos
- gtamicidin dubos
- g5amicidin dubos
- g4amicidin dubos
- grzmicidin dubos
- grsmicidin dubos
- grwmicidin dubos
- grqmicidin dubos
- granicidin dubos
- grakicidin dubos
- grajicidin dubos
- gramucidin dubos
Etymology of GRAMICIDIN DUBOS
The term "Gramicidin Dubos" is a combination of two elements: "Gramicidin" and "Dubos".
1. Gramicidin: The word "Gramicidin" is derived from the Latin word "grāmen", meaning "grass" or "grain", and "caedere", meaning "to kill" or "to cut". Gramicidin is an antimicrobial peptide derived from the soil bacteria Bacillus brevis, known for its ability to inhibit the growth of certain bacteria. It was first discovered in 1939.
2. Dubos: The term "Dubos" refers to René Jules Dubos, a French-born American microbiologist and pioneer in antibiotics research. René Dubos conducted extensive research on the antimicrobial properties of Bacillus brevis and was involved in the discovery of gramicidin.
