GENE REARRANGEMENTS Meaning and
Definition
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Gene rearrangements refer to alterations in the structure of a gene, resulting in the rearrangement, deletion, or duplication of gene segments within the genome. These rearrangements can occur during various biological processes, such as DNA replication, recombination, or repair, and can lead to significant changes in gene expression and function.
Gene rearrangements often involve the movement of DNA segments, known as exons, which contain the coding regions of genes. These exons can be rearranged or recombined in different configurations, leading to the production of altered or novel proteins. One common type of gene rearrangement is known as chromosomal translocation, where a portion of a chromosome breaks off and attaches to a different chromosome, resulting in a fusion gene.
Gene rearrangements can have important implications in various biological contexts and diseases. In certain organisms, gene rearrangements can contribute to the generation of genetic diversity and evolution. However, gene rearrangements are also associated with several human diseases, including cancer. For example, chromosomal translocations can result in the formation of fusion genes that drive abnormal cell growth and contribute to tumor development.
Detection and characterization of gene rearrangements are critical for understanding their role in disease development and progression. Techniques such as fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), and next-generation sequencing (NGS) have greatly facilitated the identification and analysis of gene rearrangements in research and clinical settings.
Common Misspellings for GENE REARRANGEMENTS
- gene rarangements
- fene rearrangements
- vene rearrangements
- bene rearrangements
- hene rearrangements
- yene rearrangements
- tene rearrangements
- gwne rearrangements
- gsne rearrangements
- gdne rearrangements
- grne rearrangements
- g4ne rearrangements
- g3ne rearrangements
- gebe rearrangements
- geme rearrangements
- geje rearrangements
- gehe rearrangements
- genw rearrangements
- gens rearrangements
- gend rearrangements
Etymology of GENE REARRANGEMENTS
The term "gene rearrangements" is a compound noun composed of two words: "gene" and "rearrangements".
The word "gene" originated from the German term "Gen" coined by Danish botanist Wilhelm Johannsen in 1909. Johannsen used this term to describe the hereditary units that pass genetic information from one generation to another. The word "gen" evolved from the Greek word "genesis", meaning "origin" or "birth".
The word "rearrangements" is derived from the verb "rearrange", which combines the prefix "re-" (meaning "again" or "back") and the word "arrange" (originating from the French term "arranger"). "Arrange" is associated with the idea of organizing or placing things in order.
