GATTERMANN REACTION Meaning and
Definition
-
The Gattermann reaction refers to a chemical reaction that involves the synthesis of an aldehyde using a benzene derivative as the starting material. This reaction is also known as the Gattermann-Koch reaction due to the contributions of two chemists, Ludwig Gattermann and Julius Arnold Koch, in its development.
The Gattermann reaction involves the introduction of a formyl group (CHO) onto the benzene compound by treating it with carbon monoxide (CO) and hydrogen chloride (HCl) in the presence of a Lewis acid such as aluminum chloride (AlCl3) as a catalyst. This reaction is typically carried out under high pressure and at elevated temperatures to facilitate the formation of the desired aldehyde product.
The reaction mechanism of the Gattermann reaction involves the formation of a complex between the benzene derivative and the Lewis acid catalyst. This complex then reacts with CO and HCl, leading to the formation of a metal carbonyl chloride intermediate. Subsequently, the intermediate undergoes a rearrangement to form an acyl chloride, and eventually results in the substitution of a hydrogen atom on the benzene ring by the formyl group. The final product obtained is an aromatic aldehyde bearing the formyl group.
The Gattermann reaction finds wide applications in organic synthesis, especially in the preparation of aldehydes for various industrial and laboratory purposes. It provides a valuable method for the introduction of the formyl group into aromatic compounds, allowing for the construction of complex organic molecules.
Common Misspellings for GATTERMANN REACTION
- fattermann reaction
- vattermann reaction
- battermann reaction
- hattermann reaction
- yattermann reaction
- tattermann reaction
- gzttermann reaction
- gsttermann reaction
- gwttermann reaction
- gqttermann reaction
- gartermann reaction
- gaftermann reaction
- gagtermann reaction
- gaytermann reaction
- ga6termann reaction
- ga5termann reaction
- gatrermann reaction
- gatfermann reaction
- gatgermann reaction
- gatyermann reaction
Etymology of GATTERMANN REACTION
The term "Gattermann reaction" refers to a specific organic chemical reaction known as the "Gattermann formylation", which was named after the German chemist Ludwig Gattermann. The etymology of the word primarily stems from Ludwig Gattermann's contribution to the development of this reaction.
Ludwig Gattermann (1860-1920) was an influential organic chemist who made significant contributions to the field, particularly in the area of synthesis. He devised a method for introducing the formyl (-CHO) group onto aromatic compounds, which came to be known as the "Gattermann formylation". This reaction allowed for the synthesis of aldehydes using a mixture of hydrogen cyanide (HCN) and hydrogen chloride (HCl) in the presence of a catalyst, typically anhydrous aluminum chloride (AlCl3).
