Gastrin Cells are specialized cells found in the lining of the stomach that produce the hormone gastrin, which stimulates the release of gastric acid. The spelling of "gastrin" can be explained using the International Phonetic Alphabet, with the /ɡ/ representing the initial sound as in "go", followed by the /æ/ as in "cat" and the /s/ sound. The final syllable is pronounced with the /t/ sound followed by the nasal consonant /ɪn/. The word "cells" contains the initial consonant cluster /s/ and /ɛl/, which is pronounced as the sound in the word "bell."
Gastrin cells, also known as G cells, are specialized endocrine cells located in the gastric glands of the stomach. These cells are primarily responsible for the secretion of a hormone called gastrin. Gastrin serves as one of the key regulators of gastric acid secretion and helps in the digestion and absorption of nutrients.
The main function of gastrin cells is to monitor the pH levels within the stomach. When the pH becomes too high (less acidic), gastrin cells are stimulated to secrete gastrin into the bloodstream. Gastrin then travels to the parietal cells of the gastric glands, triggering the release of hydrochloric acid, which helps in breaking down food and killing any potential pathogens.
In addition to stimulating acid secretion, gastrin also plays a role in promoting the growth and differentiation of gastric mucosal cells, enhancing gastric motility, and increasing blood flow to the stomach.
Abnormalities in gastrin cell function can lead to various gastrointestinal disorders. For example, overactive gastrin production can result in the condition known as Zollinger-Ellison syndrome, characterized by excessive gastric acid secretion and the formation of ulcers in the stomach and small intestine. Conversely, underactive gastrin production or a lack of gastrin cells can lead to reduced acid secretion and impair proper digestion.
In conclusion, gastrin cells are endocrine cells found in the stomach that produce the hormone gastrin, which regulates gastric acid secretion and plays a crucial role in digestion and nutrient absorption.
The word "gastrin" is derived from the Greek word "gaster", which means "stomach". "Gastrin" refers to a hormone produced by specialized cells in the stomach known as "gastrin cells". These cells play a crucial role in the regulation of gastric acid secretion and the digestion process.