GAP JUNCTION Meaning and
Definition
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A gap junction refers to a specialized intercellular connection that allows direct electrical and chemical communication between adjacent cells. It is a narrow gap between the plasma membranes of two cells, bridged by a cluster of proteins called connexins. These connexins form pore-like structures known as connexons, which align between the cells' membranes and create a channel for the transfer of small molecules and ions, typically up to 1 kilodalton in size. This mode of direct communication through gap junctions is referred to as gap junctional intercellular communication (GJIC).
Gap junctions are commonly found in many tissues and cell types throughout the body, including the nervous system, heart, and various organs. They play a crucial role in coordinating and synchronizing cellular activities, allowing rapid transmission of signals and exchange of important cellular molecules. Through gap junctions, cells can synchronize their electrical activities, enabling coordinated contraction in cardiac muscle cells or coordinated firing of neurons. Additionally, they facilitate the transport of metabolites, second messengers, and signaling molecules, facilitating intercellular communication and coordination.
Defects or abnormalities in gap junctions can lead to various diseases and disorders, including cardiac arrhythmias, certain neurological disorders, and some forms of deafness. Research into the structure and function of gap junctions continues to shed light on their role in cellular communication and their potential implications in human health.
Common Misspellings for GAP JUNCTION
- fap junction
- vap junction
- bap junction
- hap junction
- yap junction
- tap junction
- gzp junction
- gsp junction
- gwp junction
- gqp junction
- gao junction
- gal junction
- ga- junction
- ga0 junction
- gap hunction
- gap nunction
- gap munction
- gap kunction
- gap iunction
- gap uunction
Etymology of GAP JUNCTION
The word "gap junction" is derived from the combination of "gap" and "junction".
The term "gap" refers to the small spaces or gaps that exist between adjacent cells in tissues or organs. These gaps are crucial for intercellular communication and allow for the exchange of small molecules and ions between cells.
The word "junction" refers to a point where two or more entities meet or converge. In the case of gap junctions, it refers to the point where the membranes of neighboring cells come together, forming channels or pores that allow direct communication between the cytoplasm of those cells.
Thus, the term "gap junction" describes the specialized intercellular connection or communication channel that occurs through the gaps between adjacent cells.
