GABA AMINOTRANSFERASE Meaning and
Definition
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GABA Aminotransferase, also known as GABA-T, is an enzyme involved in the catabolism of gamma-aminobutyric acid (GABA) in the central nervous system (CNS). GABA is an important inhibitory neurotransmitter, playing a crucial role in regulating neuronal excitability. The enzyme is responsible for the conversion of GABA to succinic semialdehyde, a reaction that takes place within the mitochondrial matrix.
GABA Aminotransferase is part of the family of aminotransferase enzymes, which catalyze the transfer of an amino group from an amino acid to a keto acid, resulting in the formation of a different amino acid and keto acid. Specifically, GABA Aminotransferase transfers the amino group from GABA to alpha-ketoglutarate, forming succinic semialdehyde and glutamate.
This enzyme is widely distributed in various tissues, with the highest levels found in the CNS. It contributes to the regulation of GABA levels in the brain, maintaining a balance between GABA production and degradation. Altered activity of GABA Aminotransferase has been implicated in several neurological disorders, such as epilepsy and schizophrenia, where abnormal GABA metabolism plays a role.
The measurement of GABA Aminotransferase activity is commonly used in clinical research and serves as a potential marker for brain disorders involving GABA dysregulation. Furthermore, targeting GABA Aminotransferase may represent a potential therapeutic strategy for modulating GABAergic neurotransmission in the treatment of these conditions.
Common Misspellings for GABA AMINOTRANSFERASE
- faba aminotransferase
- vaba aminotransferase
- baba aminotransferase
- haba aminotransferase
- yaba aminotransferase
- taba aminotransferase
- gzba aminotransferase
- gsba aminotransferase
- gwba aminotransferase
- gqba aminotransferase
- gava aminotransferase
- gana aminotransferase
- gaha aminotransferase
- gaga aminotransferase
- gabz aminotransferase
- gabs aminotransferase
- gabw aminotransferase
- gabq aminotransferase
- gaba zminotransferase
- gaba sminotransferase
Etymology of GABA AMINOTRANSFERASE
The word "GABA Aminotransferase" can be broken down into its components for a clearer understanding of its etymology:
1. GABA: An acronym for Gamma-Aminobutyric Acid, a neurotransmitter in the central nervous system that plays a crucial role in regulating brain activity and muscle tone.
2. Amino: Derived from the Latin "amino", which means "related to or containing an amino group (-NH2)". In this context, it refers to the presence of the amino group within the GABA molecule.
3. Trans: Derived from the Latin "trans", which means "across" or "beyond". In this context, it implies the transfer of a functional group (in this case, an amino group) from one molecule to another.
4. Fer: Derived from the Latin "ferre", which means "to carry" or "to bear".
