FREUND ADJUVANT Meaning and
Definition
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Freund Adjuvant, also known as Complete Freund's Adjuvant (CFA), is a substance commonly used in immunology and biomedical research to enhance the immune response in laboratory animals. It was developed by Jules Freund and colleagues in the 1940s.
Freund Adjuvant is composed of a water-in-mineral oil emulsion that contains heat-killed Mycobacterium tuberculosis or other mycobacteria, as well as additional components such as inactivated pertussis toxin. The presence of these immunostimulatory agents helps to activate and amplify the immune system's response to injected antigens.
The purpose of Freund Adjuvant is to provoke a more potent and long-lasting immune response than would occur naturally following antigen exposure. This is achieved by creating an inflammation-like environment at the injection site, which recruits immune cells and enhances their activation. The mycobacteria in the adjuvant further contribute to immune activation by triggering an innate immune response.
Freund Adjuvant is primarily used when studying or developing vaccines, immunotherapies, or other treatments that require a robust immune response. It is typically administered along with the antigen of interest, such as a protein or peptide, to stimulate the immune system and produce a stronger immune reaction. Research using Freund Adjuvant has led to significant advancements in understanding immune processes and developing new therapies.
Common Misspellings for FREUND ADJUVANT
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Etymology of FREUND ADJUVANT
The term "Freund adjuvant" is named after its inventor, Jules Freund, a Hungarian-American immunologist.
Jules Freund developed the Freund's Complete Adjuvant (FCA) in the 1930s while working at the Rockefeller University in New York. An adjuvant is a substance that is added to a vaccine to enhance the immune response and increase the effectiveness of the vaccine. Freund's adjuvant is a mixture of mineral oil, usually paraffin oil, and killed Mycobacterium tuberculosis bacteria, which is used as a strong immune stimulator.
Therefore, the name "Freund adjuvant" derives from the association of the adjuvant with Jules Freund, its creator.
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