FRAMESHIFT SUPPRESSOR GENES Meaning and
Definition
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Frameshift suppressor genes are a subset of genes that have the unique ability to suppress or alleviate the potentially detrimental effects of a frameshift mutation within a coding sequence of DNA. Frameshift mutations occur when nucleotides are either inserted or deleted from a DNA sequence, causing a shift in the reading frame during translation. Consequently, this shift alters the amino acid sequence in the resulting protein, often leading to nonfunctional or truncated proteins.
Frameshift suppressor genes act as genetic modifiers that can restore the correct reading frame and allow for the production of functional proteins, despite the presence of a frameshift mutation. These genes typically encode proteins that can recognize and bind to the altered mRNA sequence, resulting in a compensatory mechanism that compensates for the disruption caused by the frameshift mutation. This binding may correct the reading frame by skipping over the extra nucleotides or by facilitating the incorporation of additional nucleotides to restore the correct reading frame.
Frameshift suppressor genes are often categorized into two main classes: true suppressors and adaptive suppressors. True suppressors are genes that can specifically correct a frameshift mutation in a particular gene sequence, restoring the original reading frame and allowing for the production of a functional protein. On the other hand, adaptive suppressors are genes that promote general mechanisms that can alleviate the effects of frameshift mutations. These genes may act at multiple loci, providing more widespread suppression of frameshift mutations.
Common Misspellings for FRAMESHIFT SUPPRESSOR GENES
- drameshift suppressor genes
- crameshift suppressor genes
- vrameshift suppressor genes
- grameshift suppressor genes
- trameshift suppressor genes
- rrameshift suppressor genes
- feameshift suppressor genes
- fdameshift suppressor genes
- ffameshift suppressor genes
- ftameshift suppressor genes
- f5ameshift suppressor genes
- f4ameshift suppressor genes
- frzmeshift suppressor genes
- frsmeshift suppressor genes
- frwmeshift suppressor genes
- frqmeshift suppressor genes
- franeshift suppressor genes
- frakeshift suppressor genes
- frajeshift suppressor genes
- framwshift suppressor genes
