FORMIMINOGLUTAMIC ACID TEST Meaning and
Definition
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The Formiminoglutamic Acid Test, also known as the FIGLU test, is a diagnostic examination conducted to evaluate the levels of formiminoglutamic acid (FIGLU) in the urine. It is primarily used to evaluate the activity of folic acid in the body and detect abnormalities related to its metabolism.
Folic acid is a vital B vitamin that plays a crucial role in various physiological processes, including the synthesis of DNA, cell division, and red blood cell formation. In order to function properly, folic acid must be converted to its active form, tetrahydrofolic acid (THFA). The conversion of folic acid to THFA requires an enzyme known as formiminotransferase, which is responsible for processing formiminoglutamic acid.
The Formiminoglutamic Acid Test measures the presence of FIGLU in the urine, which is an intermediate metabolite of folic acid metabolism. An elevated level of FIGLU indicates a deficiency or impaired function of formiminotransferase, which suggests a defect in folic acid metabolism. This could be indicative of a genetic disorder, such as formiminotransferase deficiency or an impaired folic acid absorption or utilization.
The FIGLU test is typically performed in patients with suspected folic acid metabolism disorders or individuals with symptoms such as megaloblastic anemia, developmental delay, neurological abnormalities, or macrocytic anemia. By assessing FIGLU levels, healthcare professionals can obtain valuable insights into the function of folic acid and aid in diagnosing and managing related conditions.
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