FMS Proto Oncogene Protein, also commonly referred to as c-Fms, is a type of cell surface receptor protein that plays a significant role in the regulation of processes related to cell growth, differentiation, and survival. It belongs to a family of proteins known as receptor tyrosine kinases.
The c-Fms protein is encoded by the FMS proto-oncogene, which is a gene involved in the development of certain cancers. The protein consists of an extracellular region, a transmembrane region, and an intracellular region containing a tyrosine kinase domain. Upon binding of its ligand, known as colony-stimulating factor 1 (CSF-1), c-Fms initiates a signaling cascade that results in the activation of various downstream pathways crucial for cell proliferation and survival.
The function of the c-Fms protein is particularly important in regulating the differentiation and survival of monocytes, macrophages, and their progenitor cells. It is involved in processes such as immune response, tissue repair, and bone remodeling.
Alterations or mutations in the FMS proto-oncogene can lead to dysregulation of c-Fms protein activity, resulting in abnormal cell proliferation and oncogenesis. Consequently, inhibitors targeting c-Fms activity have been developed as potential therapeutic options for certain types of cancers, including certain forms of leukemia and solid tumors.
In conclusion, the FMS Proto Oncogene Protein, c-Fms, is a cell surface receptor protein that functions as a key regulator of cell growth and survival. Its dysregulation can contribute to the development and progression of various types of cancers.
