How Do You Spell FKBP ROTAMASE?

Pronunciation: [ˌɛfkˌe͡ɪbˌiːpˈiː ɹˈə͡ʊtɐmˌe͡ɪs] (IPA)

The correct spelling of "FKBP Rotamase" is often a challenge due to the various sounds and letters involved. The word is pronounced as "eff-kay-bee-pee roh-tuh-meyz," with the stress on the second syllable. The phonetic transcription of the word is /ɛfkɛɪbiːpiː ɹɒtəmeɪz/. The letter "F" represents the sound of "eff," and "K" stands for "kay." The letters "B" and "P" represent the sounds of "bee" and "pee," respectively. Finally, the suffix "-ase" is pronounced as "eyz."

FKBP ROTAMASE Meaning and Definition

1. FKBP rotamase, also known as FKBP protein or FKBP peptidyl-prolyl cis-trans isomerase, is an enzyme belonging to the family of peptidyl-prolyl isomerases (PPIases). This class of enzymes catalyzes the conversion of peptidyl-prolyl peptide bonds between the cis and trans conformations.

   The FKBP rotamase specifically belongs to the FK506-binding protein (FKBP) family, which is widely found in various organisms, including bacteria, archaea, plants, and animals. It is named after its ability to bind to the immunosuppressive drug FK506. This enzyme plays a crucial role in regulating protein folding, trafficking, and signaling pathways within a cell.

   FKBPs possess a conserved FKBP domain, which is essential for binding to FK506 and structurally similar compounds. The catalytic activity of FKBP rotamase involves the cis-trans isomerization of proline residues in proteins. By catalyzing this isomerization, FKBP rotamase contributes to the proper folding, stability, and function of target proteins.

   Beyond its catalytic function, FKBP rotamase has been implicated in various biological processes. It has been found to interact with multiple signaling proteins, including protein kinases and receptors, modulating their activity and downstream signaling pathways. Additionally, FKBP rotamase is involved in protein-protein interactions and protein folding under conditions of stress or disease.

   The study of FKBP rotamase and its associated cellular processes has tremendous implications for understanding protein folding, cell signaling, and disease development.

Common Misspellings for FKBP ROTAMASE

• dkbp rotamase
• ckbp rotamase
• vkbp rotamase
• gkbp rotamase
• tkbp rotamase
• rkbp rotamase
• fjbp rotamase
• fmbp rotamase
• flbp rotamase
• fobp rotamase
• fibp rotamase
• fkvp rotamase
• fknp rotamase
• fkhp rotamase
• fkgp rotamase
• fkbo rotamase
• fkbl rotamase
• fkb- rotamase
• fkb0 rotamase
• fkbp eotamase

Etymology of FKBP ROTAMASE

The word "FKBP Rotamase" is a scientific term that consists of two main components: FKBP and Rotamase.

1. FKBP is an acronym for "FK506-binding protein". The name FKBP was derived from the initial discovery of this protein's ability to specifically bind to a drug called FK506, also known as Tacrolimus, which is an immunosuppressant. The FKBP proteins are a family of proteins that have a high affinity for binding to FK506, and they play various roles in cellular functions, including immunosuppression.

2. Rotamase, on the other hand, is a term coined to describe the enzymatic activity of certain proteins that catalyze the rotation of peptide bonds between cis and trans conformations.