FIGLU TEST Meaning and
Definition
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The FIGLU test is a diagnostic test used to evaluate the levels of formiminoglutamic acid (FIGLU) in the urine. FIGLU is a byproduct of the amino acid histidine metabolism. The test is particularly helpful in the diagnosis of a rare genetic disorder known as formiminoglutamic aciduria.
Formiminoglutamic aciduria is an autosomal recessive disorder that results from a deficiency of the enzyme formiminotransferase-cyclodeaminase. This enzyme is involved in the breakdown of histidine, an essential amino acid. In individuals with this disorder, the excessive accumulation of FIGLU leads to an abnormal urinary excretion of formiminoglutamic acid.
The FIGLU test involves collecting a urine sample from the patient, usually after a measured dose of histidine has been given orally. The urine sample is then analyzed in the laboratory to measure the levels of FIGLU. Elevated levels of FIGLU in the urine typically indicate a deficiency in formiminotransferase-cyclodeaminase activity and diagnosing formiminoglutamic aciduria.
By detecting the presence of FIGLU in the urine, the FIGLU test helps in differentiating formiminoglutamic aciduria from other metabolic disorders. It aids in initiating appropriate treatment and management strategies for affected individuals. Additionally, the FIGLU test is also used to monitor the response to treatment and evaluate the effectiveness of interventions in managing formiminoglutamic aciduria.
Overall, the FIGLU test is an essential tool in the diagnosis and management of formiminoglutamic aciduria, enabling healthcare professionals to provide timely and appropriate care to affected individuals.
Common Misspellings for FIGLU TEST
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Etymology of FIGLU TEST
The term "FIGLU test" is named after the substance it examines, formiminoglutamic acid (FIGLU). The etymology of "FIGLU" is as follows:
"Figlu" is an abbreviation and stands for Formiminoglutamic acid, which is composed of two parts:
1. Formimino-: This prefix indicates the presence of a formimino group. The term "formimino" comes from the Latin word "forma" meaning "shape" or "structure", and the chemical term "imino", which refers to a specific organic functional group -NH-. Thus, "formimino" refers to the shape or structure of the imino group.
2. -glutamic acid: "Glutamic acid" is an amino acid, a building block of proteins.
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