Fibrosis is a medical term that refers to the formation and accumulation of excessive fibrous connective tissue in an organ or tissue as a result of injury, inflammation, or a chronic disease process. This condition is characterized by the abnormal deposition of collagen fibers, which leads to the thickening and scarring of the affected area.
When normal tissue is damaged or destroyed, the body initiates a healing response to repair the injured area. However, in cases where the healing process is impaired or prolonged, fibrosis can occur. This excessive build-up of fibrous tissue can disrupt the normal structure and functioning of the organ or tissue, leading to various complications.
Fibrosis can affect any organ or tissue in the body, including the lungs, liver, kidney, heart, and skin. It is commonly associated with chronic diseases such as liver cirrhosis, pulmonary fibrosis, and systemic sclerosis. Fibrosis can result in the loss of organ function, reduced blood supply, impaired tissue elasticity, and increased stiffness.
Symptoms of fibrosis depend on the specific organ or tissue affected, but often include pain, difficulty breathing, fatigue, and decreased mobility. Treatment options for fibrosis aim to manage the underlying cause, control inflammation, and prevent further scarring. However, the reversal of existing fibrosis is challenging, and interventions are primarily focused on relieving symptoms and improving quality of life.
In summary, fibrosis is the excessive accumulation of fibrous connective tissue in an organ or tissue, resulting in scarring, loss of function, and potential complications.
