Fibril Associated Collagens (FACITs; also known as Fibril-Associated Collagens with Interrupted Triple helices) are a group of extracellular matrix proteins that play vital roles in maintaining the structural integrity and function of various tissues in the human body.
Fibril Associated Collagens are characterized by their unique structure, which consists of a series of triple helical domains interrupted by non-triple helical regions. This distinctive structure allows them to bind to and stabilize collagen fibrils within the extracellular matrix.
One of the main functions of FACITs is to regulate the assembly and organization of collagen fibrils, which are essential for the strength and resilience of tissues such as tendons, cartilage, and skin. By interacting with other collagen types, glycosaminoglycans, and connective tissue components, FACITs contribute to the formation of organized fibrillar networks within tissues.
Furthermore, FACITs are involved in mediating cell-matrix interactions, cell adhesion, and cell migration processes. They have been implicated in various cellular activities such as wound healing, tissue development, and homeostasis.
Mutations or dysregulation of FACIT proteins have been associated with several pathological conditions, including connective tissue disorders, such as Ehlers-Danlos syndrome, and musculoskeletal diseases, such as osteoarthritis.
In summary, Fibril Associated Collagens are a diverse group of extracellular matrix proteins that play critical roles in maintaining tissue structure and function, serving as essential components of the extracellular matrix and modulators of cellular behavior.
