FGF RECEPTOR Meaning and
Definition
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FGF receptor, also known as fibroblast growth factor receptor, refers to a class of cell surface proteins that are extensively involved in cellular signaling and play a crucial role in various physiological and pathological processes. These receptors belong to the larger family of receptor tyrosine kinases (RTKs).
FGF receptors consist of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. They are primarily activated by fibroblast growth factors (FGFs), a group of signaling proteins that bind to the receptors, initiating a cascade of downstream signaling events. Upon ligand binding, FGF receptors dimerize and undergo autophosphorylation, leading to the activation of the tyrosine kinase domains. This activation triggers signaling pathways involved in cellular processes such as cell proliferation, differentiation, migration, and survival.
There are four main isoforms of FGF receptors, namely FGFR1, FGFR2, FGFR3, and FGFR4. Each isoform has specific binding affinity for different FGF ligands, resulting in diverse biological functions. FGF receptors are crucial for embryonic development, tissue repair, blood vessel formation, and bone growth. However, aberrant activation or mutations in FGF receptors have been implicated in multiple diseases, including cancer, skeletal disorders, and developmental abnormalities.
Understanding FGF receptors and their signaling pathways has significant implications in the development of therapeutic interventions for various diseases, as interventions targeting the FGF receptor signaling have the potential to modulate cellular processes and restore normal tissue homeostasis.
Common Misspellings for FGF RECEPTOR
- cgf receptor
- vgf receptor
- tgf receptor
- fff receptor
- fvf receptor
- fbf receptor
- fhf receptor
- fyf receptor
- ftf receptor
- fgd receptor
- fgv receptor
- fgg receptor
- fgt receptor
- fgr receptor
- fgf eeceptor
- fgf deceptor
- fgf feceptor
- fgf teceptor
- fgf 5eceptor
- fgf 4eceptor
Etymology of FGF RECEPTOR
The etymology of the word "FGF Receptor" can be broken down as follows:
FGF stands for Fibroblast Growth Factor. Fibroblast is derived from the Greek word "fibro" meaning "fiber" and "blastos" meaning "germ" or "bud". Growth factor refers to a substance that stimulates growth, development, and cellular differentiation in living organisms.
Receptor comes from the Latin word "receptus", meaning "received" or "to receive". In biology, a receptor refers to a molecule or a protein on the surface of a cell that receives and binds to specific molecules (such as growth factors) to initiate a cellular response.
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