FAS RECEPTOR Meaning and
Definition
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Fas receptor, also known as Fas or CD95, is a cell surface protein that belongs to the tumor necrosis factor (TNF) receptor superfamily. It plays a crucial role in regulating apoptotic cell death, which is a highly regulated process that occurs in multicellular organisms to eliminate abnormal or damaged cells.
The Fas receptor is expressed on various cell types, including immune cells like T and B lymphocytes. It is a trimeric protein that consists of three subunits, each containing a cysteine-rich domain, a transmembrane domain, and a death domain. Upon binding with its ligand, Fas ligand (FasL), which is expressed on the surface of cytotoxic T cells and natural killer cells, Fas receptor triggers a signaling cascade that ultimately leads to the activation of caspase enzymes. Caspases are essential enzymes involved in apoptosis and their activation leads to the cleavage of various cellular proteins, resulting in cell death.
Dysregulation of the Fas receptor pathway has been implicated in various diseases, including autoimmune disorders, neurodegenerative diseases, and cancer. Mutations in the Fas receptor gene have been associated with autoimmune lymphoproliferative syndrome (ALPS), a rare disorder characterized by defective lymphocyte apoptosis and excessive lymphocyte accumulation. Moreover, evasion of Fas receptor-mediated apoptosis is a common mechanism adopted by cancer cells to resist cell death, leading to tumor progression and resistance to conventional cancer treatments.
In summary, the Fas receptor is a cell surface protein that plays a critical role in mediating apoptotic cell death. It acts as a molecular switch that is triggered by its ligand, FasL, resulting in the activation of the apoptotic pathway.
Common Misspellings for FAS RECEPTOR
- das receptor
- cas receptor
- vas receptor
- gas receptor
- tas receptor
- ras receptor
- fzs receptor
- fss receptor
- fws receptor
- fqs receptor
- faa receptor
- faz receptor
- fax receptor
- fad receptor
- fae receptor
- faw receptor
- fas eeceptor
- fas deceptor
- fas feceptor
- fas teceptor
Etymology of FAS RECEPTOR
The term "fas receptor" is derived from two sources: the word "fas" and the word "receptor".
1. Fas: The word "fas" is derived from Latin. It originates from the Latin word "fāx", which means "torch" or "light". In the context of the fas receptor, "fas" refers to the membrane protein known as Fas or CD95. Fas is involved in cell signaling and plays a crucial role in the regulation of programmed cell death, also known as apoptosis.
2. Receptor: The term "receptor" comes from the Latin word "receptus", meaning "received". In biology, a receptor is a molecular structure, such as a protein, that receives and responds to specific chemical signals, allowing cells to communicate and coordinate their activities.
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