FACTOR VIIIA Meaning and
Definition
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Factor VIIIa is a coagulation factor that plays a crucial role in the completion of the intrinsic pathway of blood coagulation. It is formed from the activation of an inactive precursor molecule called Factor VIII by the enzymatic action of thrombin. Factor VIIIa functions as a cofactor in the coagulation cascade and functions by binding to another coagulation factor called Factor IXa.
Factor VIIIa acts as a bridge between Factor IXa and Factor X, facilitating the activation of Factor X by Factor IXa. This activation transforms Factor X into its active form, Factor Xa, which then contributes to the formation of a blood clot. Therefore, Factor VIIIa is essential for blood coagulation and the prevention of excessive bleeding.
Deficiencies or mutations in Factor VIII can lead to a bleeding disorder known as hemophilia A. Hemophilia A is a hereditary condition in which the individual lacks sufficient functional Factor VIII, resulting in impaired blood clotting. Individuals with hemophilia A can experience prolonged bleeding after injuries, surgeries, or even spontaneously.
Factor VIIIa is also used therapeutically in the treatment of hemophilia A. Recombinant Factor VIIIa is produced through biotechnology, allowing the administration of clotting factors to individuals with hemophilia A to restore normal blood clotting capabilities and prevent bleeding episodes.
Common Misspellings for FACTOR VIIIA
- factor vviii
- Factor VIya
- dactor viiia
- cactor viiia
- vactor viiia
- gactor viiia
- tactor viiia
- ractor viiia
- fzctor viiia
- fsctor viiia
- fwctor viiia
- fqctor viiia
- faxtor viiia
- favtor viiia
- faftor viiia
- fadtor viiia
- facror viiia
- facfor viiia
- facgor viiia
- facyor viiia
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