EXPORTINS Meaning and
Definition
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Exportins are a group of proteins that play a crucial role in the transportation of specific molecules out of the nucleus in eukaryotic cells. They are responsible for mediating the nuclear export of a wide range of cargoes, including proteins, mRNA, and ribosomal subunits, by recognizing nuclear export signals (NES) present on these molecules.
Exportins are a part of the nuclear transport machinery, which includes importins and nuclear pore complexes. These proteins work in tandem to ensure the accurate and timely movement of molecules between the nucleus and the cytoplasm. Importins bring molecules into the nucleus, while exportins facilitate their export.
Exportins possess a unique structure consisting of multiple domains that allow them to interact with both the cargo molecules and the nuclear pore complex. The cargo-binding domain recognizes NES sequences found on the nuclear export cargo, thereby ensuring their proper recruitment. Through interactions with nucleoporins present in the nuclear pore complex, exportins facilitate the translocation of the cargo across the nuclear envelope.
The activity of exportins is tightly regulated by various cellular signaling pathways. Post-translational modifications, such as phosphorylation, can affect their affinity for cargo molecules or their interaction with nucleoporins, thus modulating the nuclear export machinery's function.
Overall, exportins are essential players in the maintenance of cellular homeostasis by regulating the movement of molecules between the nucleus and the cytoplasm.
Common Misspellings for EXPORTINS
- wxportins
- sxportins
- dxportins
- rxportins
- 4xportins
- 3xportins
- ezportins
- ecportins
- edportins
- esportins
- exoortins
- exlortins
- ex-ortins
- ex0ortins
- expirtins
- expkrtins
- explrtins
- expprtins
- exp0rtins
- exp9rtins
Etymology of EXPORTINS
The word "Exportins" is derived from the combination of two terms: "export" and "-in".
The term "export" comes from the Latin word "ex-" which means "out of" or "away from" and "portare" which means "to carry". It ultimately refers to the act of sending or transporting goods or commodities to another country for trade.
The suffix "-in" is commonly used in biology to refer to proteins or substances involved in specific functions. Thus, "exportin" would imply a protein or substance that is involved in the process of exportation.
When referring to "Exportins" in the context of cell biology, it specifically denotes a family of proteins involved in the transport of proteins from the nucleus to the cytoplasm in eukaryotic cells. These proteins recognize and bind to nuclear export signals on cargo molecules and facilitate their transport through the nuclear pore complexes.
Similar spelling words for EXPORTINS
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