How Do You Spell EUKARYOTIC TOPOISOMERASES II?

Pronunciation: [jˌuːkɐɹɪˈɒtɪk tˈɒpɔ͡ɪsˌə͡ʊmɹe͡ɪzɪz ɹˌə͡ʊmən tˈuː] (IPA)

Eukaryotic Topoisomerases II is a complex scientific term that describes a group of enzymes that manipulate DNA strands to help in replication, transcription, and chromosome condensation. Pronouncing this tongue-twister can be challenging, but using the International Phonetic Alphabet (IPA) can help. The correct pronunciation for eukaryotic is /juːˌkæriˈɒtɪk/ while the phonetic transcription for topoisomerases is /ˌtɒpəʊaɪsəˈmeɪsɪz/. The final word, II, is pronounced as a Roman numeral, which is /aɪ aɪ/.

EUKARYOTIC TOPOISOMERASES II Meaning and Definition

1. Eukaryotic Topoisomerases II refers to a group of enzymes found in eukaryotic cells that play a crucial role in DNA metabolism and chromosome management. These enzymes are responsible for modulating the topological state of DNA molecules by cutting and rejoining the DNA strands, allowing for the relaxation of supercoiled DNA and the untangling of intertwined DNA molecules.

   Eukaryotic Topoisomerases II are known as ATP-dependent enzymes, utilizing the energy from ATP hydrolysis to facilitate the breakage and rejoining of DNA strands. They achieve this by forming a covalent bond with the DNA molecule, creating a transient DNA-protein complex known as a cleavage complex. This cleavage complex allows for the controlled passage of one DNA duplex through another, thereby altering the DNA topology.

   These enzymes have various essential functions within the cell, including DNA replication, transcription, recombination, and chromosome condensation. During DNA replication, Topoisomerases II resolves the tension generated by the unwinding of the DNA helix, preventing DNA over-winding or excessive supercoiling. They also play a crucial role in chromosome condensation during mitosis and meiosis, aiding in the proper segregation of chromosomes.

   Eukaryotic Topoisomerases II are targets for several clinically significant anticancer drugs, known as Topoisomerase II inhibitors, which work by preventing the resealing of the cleaved DNA strands, leading to DNA damage and cell death. These drugs are used in cancer chemotherapy regimens to inhibit the growth of rapidly dividing cancer cells by interfering with DNA replication and transcription.

Common Misspellings for EUKARYOTIC TOPOISOMERASES II

• wukaryotic topoisomerases ii
• sukaryotic topoisomerases ii
• dukaryotic topoisomerases ii
• rukaryotic topoisomerases ii
• 4ukaryotic topoisomerases ii
• 3ukaryotic topoisomerases ii
• eykaryotic topoisomerases ii
• ehkaryotic topoisomerases ii
• ejkaryotic topoisomerases ii
• eikaryotic topoisomerases ii
• e8karyotic topoisomerases ii
• e7karyotic topoisomerases ii
• eujaryotic topoisomerases ii
• eumaryotic topoisomerases ii
• eularyotic topoisomerases ii
• euoaryotic topoisomerases ii
• euiaryotic topoisomerases ii
• eukzryotic topoisomerases ii
• euksryotic topoisomerases ii
• eukwryotic topoisomerases ii