ESTRADIOL DEHYDROGENASE Meaning and
Definition
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Estradiol dehydrogenase is an enzyme that plays a crucial role in the metabolism of estradiol, which is the most potent endogenous estrogen in mammals. It catalyzes the oxidation of estradiol, converting it into estrone, a less potent estrogen. This enzymatic reaction involves the removal of two hydrogen atoms from the estradiol molecule, resulting in the formation of a double bond and the conversion of a hydroxyl group into a keto group.
Estradiol dehydrogenase is a member of the alcohol dehydrogenase (ADH) enzyme family and is commonly found in various tissues, including the liver, ovary, and placenta. It functions as part of the overall estrogen metabolism pathway, which is responsible for regulating the levels and activities of estrogens in the body.
The activity of estradiol dehydrogenase is crucial for maintaining the balance of estrogen levels in both males and females. It contributes to the elimination of excess estradiol from the body and helps to prevent the accumulation of high levels of this hormone, which may lead to various health complications, such as hormone-related cancers, reproductive disorders, and other estrogen-dependent conditions.
Understanding the role and regulation of estradiol dehydrogenase may have implications for the development of targeted therapies for certain estrogen-related disorders and may also help in the design of drugs that modulate estrogen levels in a controlled manner.
Common Misspellings for ESTRADIOL DEHYDROGENASE
- wstradiol dehydrogenase
- sstradiol dehydrogenase
- dstradiol dehydrogenase
- rstradiol dehydrogenase
- 4stradiol dehydrogenase
- 3stradiol dehydrogenase
- eatradiol dehydrogenase
- eztradiol dehydrogenase
- extradiol dehydrogenase
- edtradiol dehydrogenase
- eetradiol dehydrogenase
- ewtradiol dehydrogenase
- esrradiol dehydrogenase
- esfradiol dehydrogenase
- esgradiol dehydrogenase
- esyradiol dehydrogenase
- es6radiol dehydrogenase
- es5radiol dehydrogenase
- esteadiol dehydrogenase
- estdadiol dehydrogenase
Etymology of ESTRADIOL DEHYDROGENASE
The word "estradiol" comes from the combination of "estrus", which refers to the period of sexual receptivity in female mammals, and "diol", which indicates that estradiol is a steroid hormone having two hydroxyl groups. "Dehydrogenase" is formed by combining the prefix "de-", which means "removal" or "absence", with "hydrogenase", indicating an enzyme that catalyzes the removal or addition of hydrogen atoms. Therefore, "Estradiol Dehydrogenase" is an enzyme involved in the chemical reaction of removing hydrogen atoms from estradiol or catalyzing other relevant reactions with estradiol.
