EPIDERMAL GROWTH FACTOR RECEPTOR KINASE Meaning and
Definition
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Epidermal Growth Factor Receptor Kinase (EGFR kinase) refers to a specific type of enzyme that is part of the family of protein kinases known as receptor tyrosine kinases. EGFR kinase plays a crucial role in cell growth, differentiation, and survival by regulating signal transduction pathways in response to the binding of epidermal growth factor (EGF) and other related ligands.
Located on the outer surface of cells, the epidermal growth factor receptor (EGFR) contains an intracellular kinase domain that can phosphorylate specific tyrosine residues on itself, as well as on other substrate proteins. The activation of EGFR kinase occurs when ligands such as EGF bind to the extracellular domain of the receptor, leading to dimerization and subsequent autophosphorylation of the intracellular kinase domain.
The phosphorylation of EGFR kinase triggers a series of intracellular signaling cascades that ultimately regulate various cellular processes. These signaling pathways are involved in the control of cell proliferation, survival, motility, and differentiation. Dysregulation of EGFR kinase activity has been implicated in numerous diseases, particularly cancer. Mutations or overexpression of EGFR kinase can lead to an aberrant activation of downstream signaling pathways, contributing to uncontrolled cell growth and the development of tumors.
EGFR kinase has become an important therapeutic target in the field of cancer treatment. Pharmacological inhibitors that specifically target EGFR kinase activity, such as small molecule tyrosine kinase inhibitors or monoclonal antibodies, have been developed to inhibit the aberrant signaling pathways associated with EGFR-driven cancers.
Common Misspellings for EPIDERMAL GROWTH FACTOR RECEPTOR KINASE
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