The word "Entwistle" is spelled with the letter combination "tw" which can be challenging for some English speakers to pronounce. The phonetic transcription of this word is /ɛnt.wɪsəl/, indicating the stress on the first syllable and the use of the "w" sound followed by a schwa sound in the second syllable. The spelling of "tw" in this word is derived from Old English, where it represented a sound similar to "tw" in "two".