ENDOGLUCOSIDASE H Meaning and
Definition
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Endoglucosidase H (Endo H) is an enzyme that plays a crucial role in glycobiology. It is a glycosidase, specifically an endoglycosidase, which hydrolyzes glycosidic bonds within the chitobiose core of N-linked oligosaccharides. N-linked oligosaccharides are complex carbohydrate chains that are attached to proteins in eukaryotic cells.
Endoglucosidase H is derived from the Aspergillus niger fungus. It specifically cleaves the α1-3-linked mannose residue present in high-mannose N-glycans, resulting in the release of a trimmed glycan structure. This enzyme is commonly employed in the field of glycoprotein analysis to obtain information about the structure and processing of N-linked glycans.
The catalytic activity of Endo H is pH dependent and is most active at slightly acidic conditions. It is commonly used in laboratory settings for glycan analysis, such as in detecting and characterizing glycosylation patterns on proteins. Moreover, it is often used in combination with other glycosidases to obtain more refined information about glycan structure.
Endoglucosidase H has proven to be a valuable tool in numerous biological and biochemical applications. Its ability to selectively cleave N-linked glycans has greatly enhanced our understanding of glycan structures, their biosynthesis, and their role in various physiological processes.
Common Misspellings for ENDOGLUCOSIDASE H
- wndoglucosidase h
- sndoglucosidase h
- dndoglucosidase h
- rndoglucosidase h
- 4ndoglucosidase h
- 3ndoglucosidase h
- ebdoglucosidase h
- emdoglucosidase h
- ejdoglucosidase h
- ehdoglucosidase h
- ensoglucosidase h
- enxoglucosidase h
- encoglucosidase h
- enfoglucosidase h
- enroglucosidase h
- eneoglucosidase h
- endiglucosidase h
- endkglucosidase h
- endlglucosidase h
- endpglucosidase h
Etymology of ENDOGLUCOSIDASE H
The word "Endoglucosidase H" is a scientific term that combines several elements to describe the enzyme's function and properties.
- "Endo" is a prefix derived from Greek, meaning "inside" or "within". In this context, it indicates that the enzyme acts on the internal or central portion of a molecule.
- "Glucosidase" is a type of enzyme that catalyzes the breakdown of glycosidic bonds in carbohydrates, specifically glucose-containing molecules.
- "H" likely refers to the specific variant or isoenzyme of endoglucosidase, as multiple variants or isoforms of enzymes may exist.
The term "Endoglucosidase H" is commonly used in scientific literature and research to describe an enzyme that acts on certain carbohydrates, particularly those containing glucose, in a specific manner or context.
Similar spelling word for ENDOGLUCOSIDASE H
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