EFABP stands for Epidermal Fatty Acid Binding Protein. It is a small cytoplasmic protein that belongs to the fatty acid binding protein (FABP) family. The FABP family comprises a group of proteins involved in the transport and metabolism of fatty acids in living organisms.
Epidermal Fatty Acid Binding Protein specifically plays a crucial role in the transportation and regulation of long chain fatty acids in the epidermal cells, which are the outermost layer of the skin. This protein is primarily expressed in the epidermis, sebaceous glands, and hair follicles.
EFABP functions as a carrier molecule that binds to long chain fatty acids inside the epidermal cells. It facilitates the transport of these fatty acids from the cytosol to various cellular compartments, aiding in important processes such as cell signaling and lipid metabolism. By facilitating the transport, EFABP helps regulate the levels of long chain fatty acids within epidermal cells, which is essential for maintaining skin barrier function and for the proper functioning, development, and differentiation of the epidermis.
Additionally, EFABP is believed to have a role in protecting the skin against various environmental stressors, such as ultraviolet radiation, oxidative stress, and inflammation. It may also play a role in the development and progression of certain skin disorders.
In summary, Epidermal Fatty Acid Binding Protein is a protein involved in the transport and regulation of long chain fatty acids in the epidermal cells of the skin.
