ECL cells, also known as enterochromaffin-like cells, are a type of neuroendocrine cell found in the gastric glands of the stomach. The spelling of "ECL" is phonetically transcribed using the International Phonetic Alphabet as /iːsiːɛl/ where /iː/ represents the long "e" sound in "E", /siː/ represents the "s" sound in "C", and /ɛl/ represents the "l" sound in "Cells". These cells secrete histamine, which stimulates the production of gastric acid by parietal cells, playing an important role in the regulation of gastric acid secretion.
ECL cells, also known as enterochromaffin-like cells, are a specific type of cells found in the gastric mucosa, which is the lining of the stomach. These cells are responsible for producing and releasing a hormone called histamine.
Histamine is a biologically active compound that plays a crucial role in regulating various functions within the body. In the context of the stomach, histamine is primarily involved in the production of gastric acid. When the stomach receives signals to initiate the process of digestion, ECL cells release histamine into the bloodstream.
Once in the bloodstream, histamine binds to specific receptors on the surface of cells known as parietal cells, which are found in the gastric glands. This leads to an increase in the secretion of gastric acid into the stomach lumen, thereby aiding in the breakdown of food.
Therefore, ECL cells and the release of histamine they mediate are significant in the regulation of stomach acid production and overall digestion. Dysregulation or dysfunction of these cells may contribute to certain gastric disorders, such as gastric ulcers, acid reflux, or excessive stomach acid production.
In conclusion, ECL cells are a type of cells present in the stomach that produce and release the hormone histamine, which plays a crucial role in regulating stomach acid production and digestion.
The term "ECL cells" is an abbreviation for "enterochromaffin-like cells". Each part of the term has its own etymology:
1. Enterochromaffin: The term "entero-" derives from the Greek word "enteron", meaning intestine. "Chroma" comes from the Greek word "chroma", which means color. And "affin" comes from the Latin word "affinis", which means connected or related. Hence, "enterochromaffin" refers to cells found in the intestines that have an affinity for staining with certain dyes and are related to color.
2. Like: "Like" is an English word that comes from Old English "gelic", which means similar or resembling. In this case, it is used to denote that ECL cells resemble chromaffin cells found in other areas of the body.