E SELECTIN Meaning and
Definition
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E-selectin is a cell adhesion molecule belonging to the selectin family, which primarily facilitates leukocyte rolling and adhesion to the endothelium present in blood vessels. It is primarily expressed in endothelial cells upon activation by various inflammatory mediators, such as cytokines and chemokines. The term "E" in E-selectin is derived from its predominant expression on activated endothelial cells.
As a critical mediator of leukocyte recruitment, E-selectin plays a crucial role in the inflammatory response and immune surveillance. It functions by binding to specific ligands, including sialyl Lewis-x (sLeX) present on the surface of leukocytes. This interaction initiates the rolling of leukocytes along the endothelial surface, allowing them to survey the vessel wall for sites of infection or tissue injury.
E-selectin also participates in various pathological conditions, such as atherosclerosis, wherein it promotes the recruitment of inflammatory cells to the arterial wall, leading to inflammation and plaque formation. Additionally, it has been implicated in the development of metastatic cancer by facilitating the attachment of circulating tumor cells to the endothelial lining of distant organs.
Understanding the precise mechanisms and regulation of E-selectin is of great significance, as targeting its function may offer potential therapeutic strategies to modulate inflammatory responses, immune surveillance, and metastasis.
Common Misspellings for E SELECTIN
- E Selectan
- E Selectmn
- E Selecthn
- E Selectif
- E Selectil
- E Selectio
- eselectinn
- e s electin
- e se lectin
- e sel ectin
- e sele ctin
- e selec tin
- e select in
- e selecti n
- n Selectin
- L Salectin
- p selectihn
Etymology of E SELECTIN
The word "E-selectin" is composed of two main parts: "E" and "selectin".
1. "E": In this context, "E" stands for "Endothelial". Endothelial cells line the interior surface of blood vessels and play a crucial role in inflammation and immune response. The use of the letter "E" in E-selectin signifies that this specific selectin is primarily expressed on endothelial cells.
2. "Selectin": The term "selectin" is derived from the word "select", indicating the specific adhesion properties of these molecules. Selectins are a family of cell adhesion molecules found on various cell surfaces, including endothelial cells, leukocytes, and platelets. They facilitate interactions between cells and are involved in processes such as inflammation, immune response, and the formation of blood clots.
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