How Do You Spell E CADHERIN?

Pronunciation: [ˈiː kˈadhəɹˌɪn] (IPA)

E Cadherin is a protein found in the body that plays a crucial role in cell adhesion. The spelling of this word can be broken down using the International Phonetic Alphabet (IPA) phonetic transcription. The "E" is pronounced as "i" like in "see" and the "Cadherin" is pronounced as "kəˈdherɪn" with the accent on the second syllable. The "c" is pronounced as "k", the "dh" as "ð" like in "that", and the "e" is pronounced as "ə" like in "the". This spelling helps scientists communicate effectively and accurately about this important protein.

E CADHERIN Meaning and Definition

1. E-cadherin is a transmembrane protein that plays a crucial role in cellular adhesion, specifically in maintaining the integrity and stability of epithelial tissues. It belongs to the cadherin superfamily and is encoded by the CDH1 gene. E-cadherin is typically found on the surface of epithelial cells, where it forms part of adherens junctions, which are specialized microstructures that connect neighboring cells.

   Functionally, E-cadherin facilitates the binding of cells to each other through calcium-dependent homophilic interactions. This means that E-cadherin molecules on one cell bind to E-cadherin molecules on an adjacent cell, forming strong adhesion between the cells. These adhesions are necessary for tissue integrity and provide mechanical strength to epithelial layers.

   E-cadherin is involved in several crucial cellular processes, including embryonic development, tissue morphogenesis, and maintenance of tissue architecture. It is also essential for cell polarity, cell migration, and wound healing. Loss or dysfunction of E-cadherin can disrupt these processes, leading to various pathologies, such as cancer metastasis and developmental disorders.

   Furthermore, E-cadherin is an important tumor suppressor, as it limits cancer progression by maintaining tissue organization and inhibiting invasion of neighboring tissues. Reduced expression or mutations in the CDH1 gene, which encodes E-cadherin, are commonly associated with the loss of cell adhesion and an increased risk of developing certain cancers, particularly those of epithelial origin.

   In summary, E-cadherin is a transmembrane protein that mediates calcium-dependent cell-to-cell adhesion and is critical for maintaining tissue integrity and suppressing cancer progression.

Common Misspellings for E CADHERIN

• E Cadhevin
• E Cadhepin
• E Cadhesin
• E Cadheryn
• E Cadheran
• E Cadhermn
• E Cadherhn
• E Cadherif
• E Cadheril
• E Cadherio
• ecadherinn
• e c adherin
• e ca dherin
• e cad herin
• e cadh erin
• e cadhe rin
• e cadher in
• e cadheri n

Etymology of E CADHERIN

The term "E-cadherin" is derived from the Greek word "cadherin", which means "to adhere" or "to stick together". The "E" prefix stands for "epithelial", indicating that this particular type of cadherin molecule is found in epithelial cells. E-cadherin is a type of transmembrane protein that mediates calcium-dependent cell-cell adhesion, playing a crucial role in maintaining the integrity and structure of epithelial tissues.