DMETS CDER stands for Drug Metabolism and Transporter-Enzyme System Clinical Decision Support System (CDER). It is a system developed by the Center for Drug Evaluation and Research (CDER) of the U.S. Food and Drug Administration (FDA) to aid in making informed clinical decisions related to drug metabolism and transport.
Drug metabolism refers to the process by which the body converts drugs into various substances through chemical reactions. It involves enzymes that break down drugs into metabolites that can be eliminated from the body. Drug transporters, on the other hand, are proteins that facilitate the movement of drugs across cell membranes, influencing their distribution and elimination.
The DMETS CDER system is designed to provide healthcare professionals with valuable information about how drugs are metabolized and transported within the body. It incorporates an extensive database of drugs, their metabolites, and relevant enzymes and transporters. By inputting specific drug information, such as the drug name or active ingredient, the system can generate comprehensive data on the drug's metabolism and transport characteristics.
This decision support system assists healthcare providers in determining potential drug-drug interactions, identifying drugs that may be affected by specific genetic variations that influence drug metabolism or transport, and predicting the impact of drug transporters on drug efficacy and safety.
The DMETS CDER system helps healthcare professionals make evidence-based decisions regarding drug treatment, dosage adjustments, and medication selection for individual patients, thus enhancing patient care and safety.
