How Do You Spell DINUCLEOTIDE REPEAT?

Pronunciation: [dˈɪnjuːklˌɪətˌa͡ɪd ɹɪpˈiːt] (IPA)

The spelling of the word "Dinucleotide Repeat" can be tricky. The stress falls on the second syllable, which is pronounced as /nuːklaɪət/ - with the stress on the "kla" syllable. The "di" prefix is pronounced as /daɪ/, and the "repeat" ending is pronounced as /rɪˈpiːt/. Therefore, the full phonetic transcription for "Dinucleotide Repeat" is /daɪˈnuːklaɪət riːˈpiːt/. This type of repetition is common in genetics research, where it refers to a repeated sequence of two nucleotides in a DNA strand.

DINUCLEOTIDE REPEAT Meaning and Definition

1. A dinucleotide repeat, also known as a di- (two) nucleotide tandem repeat or microsatellite, is a specific type of genetic variation found within DNA sequences. It refers to consecutive repetitions of a particular sequence consisting of two nucleotides. In the context of the human genome, dinucleotide repeats usually contain the nucleotides adenine and thymine (AT) or cytosine and guanine (CG). For instance, the sequence AGAGAGAGAGAGAGAGAGAG is an example of a dinucleotide repeat, wherein the dinucleotide AG repeats in tandem.

   Dinucleotide repeats are considered simple sequence repeats (SSRs), as they consist of short, repetitive motifs. These repeats are highly polymorphic and show significant variability among individuals in terms of the number of repetitions present in a given DNA sequence. The variation occurs due to instability in copying processes during DNA replication. Therefore, the number of repeats can differ not only between individuals but also within a given individual's genome. This inherent instability makes dinucleotide repeats useful tools in genetic analysis, such as for identifying and studying human genetic traits and diseases.

   Furthermore, dinucleotide repeats have been associated with several genetic disorders. Expansions or contractions of dinucleotide repeats beyond a certain range can lead to genetic mutations, affecting the function of specific genes. These mutations may disturb protein synthesis, structure, or function, potentially causing genetic disorders. Therefore, the study of dinucleotide repeats holds significance in understanding the molecular basis of various genetic diseases and in the development of genetic diagnostic tests.

Common Misspellings for DINUCLEOTIDE REPEAT

• sinucleotide repeat
• xinucleotide repeat
• cinucleotide repeat
• finucleotide repeat
• rinucleotide repeat
• einucleotide repeat
• dunucleotide repeat
• djnucleotide repeat
• dknucleotide repeat
• donucleotide repeat
• d9nucleotide repeat
• d8nucleotide repeat
• dibucleotide repeat
• dimucleotide repeat
• dijucleotide repeat
• dihucleotide repeat
• dinycleotide repeat
• dinhcleotide repeat
• dinjcleotide repeat
• dinicleotide repeat

Etymology of DINUCLEOTIDE REPEAT

The word "dinucleotide" comes from the combination of two components: "di-" and "nucleotide".

The prefix "di-" is derived from the Greek word "dis", meaning "twice" or "two". In terms of chemistry and biology, "di-" is commonly used to indicate two or twice.

The term "nucleotide" refers to the building blocks of nucleic acids (such as DNA and RNA), which are the molecules responsible for storing and transmitting genetic information. Nucleotides consist of three components: a phosphate group, a sugar molecule (deoxyribose in DNA), and a nitrogenous base (adenine, thymine, cytosine, or guanine).

Therefore, when combined, "dinucleotide" literally means "two nucleotides". In the context of molecular biology, it refers to a sequence of two consecutive nucleotides.