How Do You Spell DIHYDROLIPOAMIDE DEHYDROGENASE?

Pronunciation: [da͡ɪhˈa͡ɪdɹəlˌɪpə͡ʊmˌa͡ɪd dˌiːha͡ɪdɹˈə͡ʊd͡ʒne͡ɪs] (IPA)

The spelling of the word "Dihydrolipoamide Dehydrogenase" can be a bit daunting at first glance. However, understanding the International Phonetic Alphabet (IPA) can make it easier to understand the pronunciation and spelling of such complicated words. In IPA, "Dihydrolipoamide Dehydrogenase" is pronounced as /daɪˌhaɪdroʊlɪpoʊˌaɪd dihˌhaɪdroʊdʒɪˌneɪz/. This spelling is meant to accurately capture the specific sounds made in the word, allowing professionals to easily communicate technical terms with one another.

DIHYDROLIPOAMIDE DEHYDROGENASE Meaning and Definition

1. Dihydrolipoamide dehydrogenase, also known as DLDH or E3, is an enzyme that plays a crucial role in various metabolic pathways within the cell. It is a flavoprotein enzyme primarily found in the mitochondria, the powerhouse of the cell, where it catalyzes an essential step in the process of energy production.

   The enzyme serves as a key component of the pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acid dehydrogenase complex. These complexes are responsible for the conversion of pyruvate, alpha-ketoglutarate, and branched-chain alpha-keto acids, respectively, into acetyl-CoA molecules. Acetyl-CoA is a critical intermediate in the citric acid cycle, also known as the Krebs cycle, where it participates in the production of cellular energy in the form of ATP.

   Dihydrolipoamide dehydrogenase acts as an electron carrier in these metabolic pathways, transferring electrons from the reactive sulfhydryl group of the lipoyl domain to the electron acceptor FAD (flavin adenine dinucleotide), which is bound to the enzyme. This enzymatic reaction is crucial for the regeneration of the lipoyl domain, allowing it to participate in subsequent rounds of catalysis.

   Mutations or deficiencies in dihydrolipoamide dehydrogenase have been associated with several metabolic disorders, such as pyruvate dehydrogenase deficiency and the genetic disorder known as E3 deficiency. These conditions can lead to impairments in energy production and various neurological symptoms due to the disruption of key metabolic pathways in the cell.

Common Misspellings for DIHYDROLIPOAMIDE DEHYDROGENASE

• sihydrolipoamide dehydrogenase
• xihydrolipoamide dehydrogenase
• cihydrolipoamide dehydrogenase
• fihydrolipoamide dehydrogenase
• rihydrolipoamide dehydrogenase
• eihydrolipoamide dehydrogenase
• duhydrolipoamide dehydrogenase
• djhydrolipoamide dehydrogenase
• dkhydrolipoamide dehydrogenase
• dohydrolipoamide dehydrogenase
• d9hydrolipoamide dehydrogenase
• d8hydrolipoamide dehydrogenase
• digydrolipoamide dehydrogenase
• dibydrolipoamide dehydrogenase
• dinydrolipoamide dehydrogenase
• dijydrolipoamide dehydrogenase
• diuydrolipoamide dehydrogenase
• diyydrolipoamide dehydrogenase
• dihtdrolipoamide dehydrogenase
• dihgdrolipoamide dehydrogenase

Etymology of DIHYDROLIPOAMIDE DEHYDROGENASE

The word "Dihydrolipoamide Dehydrogenase" has a scientific etymology.

"Dihydrolipoamide" is derived from "dihydro" meaning "two hydrogen atoms" and "lipoamide" which refers to a compound containing two thiol groups.

"Dehydrogenase" is a term commonly used in biochemistry to describe an enzyme that catalyzes the removal (de-) of hydrogen (-hydrogen-) atoms from a molecule.

Therefore, "Dihydrolipoamide Dehydrogenase" refers to an enzyme that catalyzes the removal of hydrogen atoms from a dihydrolipoamide molecule.

This name follows the convention in biochemistry to describe enzymes based on their specific reaction and substrate.