Correct spelling for the English word "DIHS" is [dˈɪz], [dˈɪz], [d_ˈɪ_z] (IPA phonetic alphabet).
DIHS stands for Drug-Induced Hypersensitivity Syndrome. It is a medical term used to describe a severe and potentially life-threatening adverse drug reaction. DIHS is characterized by a constellation of symptoms, including fever, skin rash, multi-organ involvement, and internal organ damage. This syndrome typically occurs within weeks to months after initial exposure to a medication, especially certain types of drugs that are known to commonly cause hypersensitivity reactions.
The exact underlying mechanism of DIHS is still not fully understood, but it is believed to be an immune-mediated reaction. The body's immune system recognizes the drug as a foreign substance and launches an exaggerated immune response, leading to the widespread inflammation and tissue damage seen in DIHS. Some common medications known to be associated with DIHS include anticonvulsants, antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), and certain psychiatric medications.
DIHS is a serious condition that requires immediate medical attention. The diagnosis is typically made based on clinical presentation, medical history, and exclusion of other possible causes. Treatment involves discontinuing the offending medication and providing supportive care, such as intravenous fluids, antihistamines, and corticosteroids to alleviate symptoms and manage complications. In some cases, hospitalization may be necessary, particularly if there is organ involvement or systemic complications.
Overall, DIHS is a severe adverse drug reaction that should not be underestimated. Prompt recognition and appropriate management are crucial in order to prevent complications, minimize organ damage, and ensure patient safety.