DESIALYLATED Meaning and
Definition
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Desialylated is an adjective used to describe a substance, typically a glycoprotein or glycolipid, which has undergone the process of removing or losing its sialic acid residues. Sialic acid is a type of sugar molecule that is commonly found at the terminal position of polysaccharide chains in these biomolecules. The process of desialylation can occur naturally or can be induced by certain enzymatic reactions, chemical treatments, or physiological conditions.
Desialylation of a glycoprotein or glycolipid refers to the removal of one or more sialic acid residues from its structure. This modification can result in changes to the protein's physical properties, such as its molecular weight, charge, and solubility. Additionally, desialylation can affect the protein's biological functions, including its ability to recognize specific targets, interact with other molecules, or participate in cellular signaling processes.
The desialylation process can have significant implications in various biological systems, as sialic acid residues often play crucial roles in numerous cellular processes. For example, desialylated glycoproteins have been associated with alterations in immune response, cell adhesion, viral infection, and cancer progression. Desialylation can also impact the pharmacokinetics and pharmacodynamics of therapeutic glycoproteins, influencing their stability, distribution, and clearance in the body.
In summary, the term "desialylated" refers to the state of a substance, typically a glycoprotein or glycolipid, after the removal or loss of its sialic acid residues. This modification can lead to changes in its physical and functional properties, with potential implications in various physiological and pathological processes.
Common Misspellings for DESIALYLATED
- sesialylated
- xesialylated
- cesialylated
- fesialylated
- resialylated
- eesialylated
- dwsialylated
- dssialylated
- ddsialylated
- drsialylated
- d4sialylated
- d3sialylated
- deaialylated
- dezialylated
- dexialylated
- dedialylated
- deeialylated
- dewialylated
- desualylated
- desjalylated
Etymology of DESIALYLATED
The word "desialylated" is derived from the combination of two components: "de-" and "sialylated".
The prefix "de-" is a Latin-derived prefix meaning "undoing" or "removal". It indicates the act of reversing or removing something.
The word "sialylated" is formed from the term "sialic acid", which is a type of acidic sugar molecule found on the surface of various cells and proteins. Sialic acids often play essential roles in cell recognition and communication processes.
Therefore, when combined, "desialylated" refers to the process of removing or reversing the presence of sialic acid from a molecule or structure.
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