Des Asp Angiotensin II is a term used in the field of biochemistry and pharmacology to refer to a specific compound formed through enzymatic processing of Angiotensin I. It is a peptide hormone that plays a critical role in the regulation of blood pressure and fluid balance in the human body.
Des Asp Angiotensin II is derived from the precursor molecule Angiotensin I, which is primarily produced and secreted by the liver. The conversion of Angiotensin I to Des Asp Angiotensin II occurs through the action of the enzyme angiotensin-converting enzyme (ACE). This enzyme removes the N-terminal dipeptide (Asp-Arg) from Angiotensin I, resulting in the formation of the active hormone Des Asp Angiotensin II.
Des Asp Angiotensin II acts on specific receptors located in various tissues and organs, including blood vessels, adrenal glands, and the kidneys. Binding of the hormone to these receptors triggers a cascade of physiological responses, including vasoconstriction (narrowing of blood vessels), stimulation of aldosterone production (a hormone involved in fluid balance), and release of other vasoactive substances.
The effects of Des Asp Angiotensin II on the body ultimately lead to increased blood pressure, water retention, and sodium reabsorption. These actions are crucial in maintaining overall blood volume and pressure regulation. Pharmacologically, the hormone can be targeted by specific inhibitors, such as ACE inhibitors or angiotensin receptor blockers, as part of the management of hypertension and other cardiovascular conditions.
In conclusion, Des Asp Angiotensin II is a biologically active peptide hormone formed by enzymatic processing of Angiotensin I, playing a central role in
