Dahl Salt Sensitive Rats (DSSR) are a specially bred strain of laboratory rats that display a genetic susceptibility to develop hypertension (high blood pressure) in response to a high-salt diet. These rats are widely used in scientific research to study the underlying mechanisms and potential treatments for hypertension and related cardiovascular diseases.
The DSSR strain was developed by the American physiologist and pharmacologist, Dr. Lewis Dahl, in the mid-20th century. The rats were selectively bred over several generations to exhibit an enhanced sensitivity to high dietary salt. When exposed to excessive levels of salt in their diet, DSSR rats experience a significant rise in blood pressure, mimicking the hypertensive response observed in some humans.
It is important to note that not all laboratory rats are salt-sensitive, and DSSR rats have been selectively bred to display this trait. This genetic trait makes them a valuable model organism for studying the effects of dietary salt on blood pressure regulation and identifying potential targets for therapeutic interventions.
The use of DSSR rats in research provides scientists with a standardized model to study the genetic, physiological, and biochemical mechanisms associated with hypertension. By investigating the impact of various interventions, such as pharmaceutical drugs or lifestyle changes, on blood pressure regulation in these rats, researchers can gain insights into the pathophysiology of hypertension and develop novel treatment strategies.
Overall, DSSR rats are an essential tool in cardiovascular research, enabling scientists to deepen their understanding of hypertension and develop new strategies to prevent or manage this prevalent health condition.
