Cytotoxic antibiotics are powerful drugs that are used to destroy cancer cells. Cytotoxic is pronounced /saɪtəʊˈtɒksɪk/, with the stress on the second syllable. The first syllable is pronounced like "sight" without the "gh" sound. The "o" in the second syllable is pronounced like "owe." Antibiotics is pronounced /æntibaɪˈɒtɪks/, with the stress on the third syllable. The "a" in the first and third syllables is pronounced like "uh." The "o" in the second syllable is pronounced like "awe."
Cytotoxic antibiotics are a class of drugs that possess the ability to kill or inhibit the growth of cancer cells by targeting and damaging their DNA. These antibiotics exhibit cytotoxic (cell-killing) properties due to their ability to intercalate into the DNA helix and disrupt its structure during replication or transcription processes. This interference with DNA synthesis or repair leads to the occurrence of lethal mutations in cancer cells, preventing their proliferation and ultimately inducing cell death.
Cytotoxic antibiotics are typically natural products derived from microorganisms, such as bacteria or fungi. They include well-known drugs like doxorubicin, bleomycin, and mitomycin, among others. These antibiotics are administered via intravenous injection or infusion and are widely used in the treatment of various types of cancers, including breast, lung, prostate, and leukemia.
Despite their name, cytotoxic antibiotics are not exclusively active against cancer cells and can also exhibit toxic effects on healthy cells. This is due to their non-specific mode of action, as they can affect any dividing cell. Consequently, the use of these drugs can cause various adverse effects, such as bone marrow suppression, hair loss, nausea, and increased susceptibility to infections.
In summary, cytotoxic antibiotics are a class of drugs that exert their anti-cancer effects by interfering with DNA replication and repair processes in cancer cells. While effective in treating cancers, their non-specificity can lead to toxic effects on healthy cells, necessitating careful management of their use.
The etymology of the term "cytotoxic antibiotics" can be broken down as follows:
1. Cytotoxic: The word "cytotoxic" is derived from two Greek roots - "cyto" meaning cell and "toxicos" meaning poison. Therefore, cytotoxic refers to substances that are toxic or poisonous to cells.
2. Antibiotics: The word "antibiotics" originates from two Greek words - "anti" meaning against, and "bios" meaning life. Antibiotics are substances that are used to inhibit the growth of, or kill bacteria or other microorganisms.
So, combining these two components, "cytotoxic antibiotics" refers to a class of antibiotics that can selectively kill or inhibit the growth of specific types of cells, particularly cancer cells, by exerting toxic effects on them.