CYCLOPHILINS Meaning and
Definition
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Cyclophilins are a family of proteins that belong to the peptidyl-prolyl cis-trans isomerase (PPIase) enzyme class. They are conserved in a wide range of species including humans, animals, plants, and microorganisms. Cyclophilins are known to play essential roles in numerous cellular processes due to their ability to catalyze the isomerization of peptide bonds involving proline residues.
The primary function of cyclophilins is to assist in the correct folding of proteins during synthesis and ensure their proper functioning. They promote conformational changes by catalyzing the cis-trans isomerization of peptidyl-prolyl bonds, which is critical for protein folding and stability. This enzymatic activity is particularly relevant for proteins that contain proline residues, as these have a propensity to adopt the cis conformation, which can hinder proper folding.
Cyclophilins have also been implicated in various cellular processes beyond protein folding. They have been shown to act as molecular chaperones, assisting in the transport of proteins across cell membranes. Additionally, cyclophilins are involved in signal transduction pathways, particularly those mediated by immunosuppressive drugs like cyclosporine A. They interact with cyclosporine A and form a complex that inhibits the activity of calcineurin, an enzyme crucial for T-cell activation and immune response.
In summary, cyclophilins are a group of proteins that possess peptidyl-prolyl cis-trans isomerase activity, which is essential for protein folding, stability, and proper functioning. Their role extends beyond protein folding, encompassing functions as molecular chaperones and modulators of immune response pathways.
Common Misspellings for CYCLOPHILINS
- xyclophilins
- vyclophilins
- fyclophilins
- dyclophilins
- ctclophilins
- cgclophilins
- chclophilins
- cuclophilins
- c7clophilins
- c6clophilins
- cyxlophilins
- cyvlophilins
- cyflophilins
- cydlophilins
- cyckophilins
- cycpophilins
- cycoophilins
- cycliphilins
- cyclkphilins
- cycllphilins
Etymology of CYCLOPHILINS
The word "Cyclophilins" is derived from two parts: "Cyclo" and "philins".
1. "Cyclo" - The prefix "Cyclo" is derived from the Greek word "kuklos" meaning "circle" or "wheel". It is commonly used in scientific terminology to refer to a cyclic or ring structure.
2. "Philins" - The suffix "-philin" is derived from the Greek word "philos" meaning "loving" or "having an affinity for". It is used to describe proteins or molecules that have an affinity or attraction towards something specific.
Therefore, "Cyclophilins" refers to a group of proteins or molecules with an affinity or attraction towards cyclic or ring structures.
Similar spelling words for CYCLOPHILINS
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