Correct spelling for the English word "colyone" is [kˈɒlɪˌə͡ʊn], [kˈɒlɪˌəʊn], [k_ˈɒ_l_ɪ__ˌəʊ_n] (IPA phonetic alphabet).
A chemical substance, formed in one organ or part of the body, and carried in the blood to another organ or part, the functional activity of which it diminishes or inhibits; the opposite of hormone.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.