COHNS TEST Meaning and
Definition
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Cohn's test refers to a specific diagnostic procedure used in the field of clinical hematology to determine the presence of cold agglutinins in a person's blood. Cold agglutinins are a type of antibody that can cause red blood cells to clump together (agglutination) when exposed to cold temperatures, leading to various medical conditions.
During a Cohn's test, a blood sample is taken from the patient and gradually cooled. The cooling process is done in a controlled manner to mimic the physiological changes that occur when blood travels from the body's core to the extremities, where colder temperatures are encountered. The sample is then observed under a microscope to check for the presence of agglutination or clumping. If clumping occurs at temperatures above normal body temperature, it indicates the presence of cold agglutinins.
Cohn's test is particularly useful in diagnosing conditions such as cold agglutinin disease, which is characterized by the destruction of red blood cells due to cold agglutinins. It is also used to distinguish other conditions that may present similar symptoms, such as autoimmune hemolytic anemia. The test provides valuable information for healthcare professionals in planning appropriate management and treatment strategies for patients with these conditions.
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