How Do You Spell COFORMYCIN?

Pronunciation: [kˈɒfɔːmˌɪsɪn] (IPA)

Coformycin is a word that is spelled exactly as it sounds. It has five syllables with the primary stress on the second syllable (-FOR-). The word comprises sounds of both consonants and vowels, starting with the voiceless velar plosive /k/ followed by the diphthong /oʊ/. The third syllable consists of the voiced alveolar fricative /z/ and the penultimate syllable is stressed with the long vowel /aɪ/. The final syllable has the nasal consonant /n/ followed by the vowel /ɪ/.

COFORMYCIN Meaning and Definition

1. Coformycin is a term that refers to a potent antibiotic agent isolated from various Streptomyces species, including Streptomyces purpurascens, Streptomyces lavendulae, and Streptomyces violaceoruber. It belongs to the class of antibiotics known as nucleoside analogs.

   The term coformycin specifically describes a compound called 2'-deoxycoformycin (a.k.a. pentostatin), which is a synthetic analog of the natural antileukemic nucleoside, 2'-deoxyadenosine. It inhibits the enzyme adenosine deaminase, which plays a crucial role in the metabolism of purine nucleosides. By inhibiting this enzyme, coformycin disrupts the normal conversion of adenosine to its metabolites, leading to the accumulation of toxic levels of deoxyadenosine triphosphate in the cells. This ultimately results in the suppression of DNA synthesis and cell division, contributing to its antimicrobial and antineoplastic activities.

   Due to its potent inhibitory action on adenosine deaminase, coformycin has found utility in both cancer treatment and the treatment of certain infections caused by Gram-positive bacteria. It has primarily been used in the treatment of hairy cell leukemia, a rare type of B-cell lymphoid neoplasm. Coformycin has also demonstrated activity against certain Gram-positive pathogens, such as Staphylococcus epidermidis and Staphylococcus aureus.

   However, it is important to note that coformycin is a highly toxic compound and can cause severe adverse effects, including myelosuppression, immunosuppression, and hepatotoxicity. Therefore, its use is strictly monitored and administered under the

Common Misspellings for COFORMYCIN

• xoformycin
• voformycin
• foformycin
• doformycin
• ciformycin
• ckformycin
• clformycin
• cpformycin
• c0formycin
• c9formycin
• codormycin
• cocormycin
• covormycin
• cogormycin
• cotormycin
• corormycin
• cofirmycin
• cofkrmycin
• coflrmycin
• cofprmycin

Etymology of COFORMYCIN

The word "Coformycin" is a compound word derived from two components: "co-" and "formycin".

1. "Co-" is a prefix used to denote collaboration, joint action, or mutual involvement. It comes from the Latin word "cum", meaning "with" or "together". In this context, "co-" suggests that the compound consists of multiple parts working together.

2. "Formycin" is the second component of the word. It is a drug that belongs to the family of nucleoside antibiotics, known as a nucleoside analog. Formycin itself is derived from the combination of two elements: "formyl-" and "-mycin".

- "Formyl-" is derived from the term "formic acid", which refers to a naturally occurring acid found in the venom of certain ants. Formic acid comes from the Latin word "formica", meaning "ant".