Coagulation necrosis refers to the process by which injured tissue is transformed into a firm, dry mass after coagulation of its proteins. The word's spelling is based on the Latin term coagulatio, meaning "coagulation," and the Greek word nekros, meaning "dead." It is pronounced as [koh-ag-yuh-LEY-shuhn neh-KRO-sis], where the "coagulation" is pronounced as "koh-ag-yuh-LEY-shuhn" with a stress on the "ley," and "necrosis" is pronounced as "neh-KRO-sis" with a stress on the "kro."
Coagulation necrosis refers to a type of tissue death that occurs as a result of injury or disease, where the affected tissue undergoes a coagulative process that leads to its demise. This process typically occurs in solid tissues, such as the liver, heart, kidney, and lungs.
Coagulation necrosis is characterized by a series of changes in the affected tissue. First, an injury or insult disrupts the blood supply to the area, resulting in oxygen and nutrient deprivation. This lack of blood flow leads to the accumulation of various toxic materials and a buildup of metabolic waste products within the tissues.
Furthermore, due to the interruption of blood flow, the affected tissue is unable to remove or dilute these toxic substances. As a result, cellular death occurs, leading to the formation of a firm, dry, and pale area of dead tissue.
The term "coagulation" in coagulation necrosis describes the morphological changes that occur during cellular death. The denatured proteins within the cells clump together, creating a solid or coagulated appearance. Additionally, the affected tissue loses its normal cell architecture and becomes more solidified or organized.
Overall, coagulation necrosis is a pathological process where tissue death occurs due to the interruption of blood supply, resulting in cellular death, alteration of tissue architecture, and the formation of a firm and solid area of necrotic tissue.
A condition accompanying infarcts, especially of the kidney and spleen, the affected area being converted into a firm, rather homogeneous mass, the process being one of coagulation of proteins of the part, similar to, or identical with, that occurring in coagulation of blood-serum by a bacterial enzyme.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "coagulation" comes from the Latin word "coagulare", which means "to curdle or congeal". "Necrosis", on the other hand, is derived from the Greek word "nekrosis", meaning "death". When these terms are combined, the term "coagulation necrosis" refers to a type of tissue damage or cell death characterized by the formation of clots or coagulation.