Cis retinal is a compound found in the human eye, crucial for vision. The word "cis" comes from the Latin for "on this side," and "retinal" is a derivative of "retina." The phonetic transcription of this word would be /sɪs rɛtɪnəl/ where the "s" is pronounced as the letter "s" and "ɪ" represents the vowel sound in "bit." The "ɛ" represents the vowel sound in "bet," the "t" and "n" are pronounced clearly and the last syllable ends with the "əl" sound found at the end of "bottl."
Cis retinal refers to a specific form of retinal, which is a natural derivative of vitamin A. Retinal is a vital component of the visual pigment rhodopsin, found in the rods of the retina in the eye. The term "cis" denotes the spatial arrangement of atoms in the molecule, where the two carbon atoms forming the double bond are on the same side of the molecule.
Cis retinal plays a crucial role in the process of vision. When light enters the eye, it stimulates rhodopsin, causing cis retinal to change conformation into its trans form. This activation of cis retinal initiates a cascade of biochemical reactions, leading to the generation of electrical signals that travel to the brain, ultimately resulting in visual perception. After this activation, trans retinal is converted back to cis retinal with the help of enzymes, allowing the visual pigment to be regenerated and maintain visual sensitivity.
The precise arrangement of atoms in cis retinal is vital for its functional role in vision. Alterations in the cis-retinal structure can lead to visual impairments or conditions such as night blindness.
Cis retinal is also employed in various biochemical and medical applications. It is widely used in laboratory research as a key component in the study of visual phototransduction processes and the manipulation of retinal cells. Furthermore, cis retinal is utilized in the development of artificial retinal prostheses, which aim to restore vision in individuals with certain forms of blindness.
The term "cis Retinal" has its etymology rooted in the field of chemistry and biology.
The word "retinal" refers to a form of vitamin A that is an essential component of the visual pigment in the retina of the eye. It plays a crucial role in the process of vision by absorbing light and triggering electrical signals that are sent to the brain.
The prefix "cis" comes from Latin and means "on this side" or "on the same side". In this context, "cis" is used to describe the spatial orientation of the double bond in the retinal molecule. There are two isomeric forms of retinal: cis retinal and trans retinal, which differ in the arrangement of their double bonds.
Therefore, the term "cis retinal" refers to the isomeric form of retinal where the double bond is oriented on the same side of the molecule.