How Do You Spell CILIARY NEUROTROPHIC FACTOR RECEPTOR?

Pronunciation: [sˈɪli͡əɹɪ njˌuːɹətɹˈɒfɪk fˈaktə ɹɪsˈɛptə] (IPA)

The spelling of the word "Ciliary Neurotrophic Factor Receptor" can be explained with the use of the International Phonetic Alphabet (IPA). The first part of the word, "Ciliary," is pronounced /ˈsɪliəri/. The second part, "Neurotrophic," is pronounced /njʊərəʊˈtrɒfɪk/. The third part, "Factor," is pronounced /ˈfæktər/. Finally, the last part, "Receptor," is pronounced /rɪˈsɛptər/. Altogether, the pronunciation of "Ciliary Neurotrophic Factor Receptor" is /ˈsɪliəri njʊərəʊˈtrɒfɪk ˈfæktər rɪˈsɛptər/.

CILIARY NEUROTROPHIC FACTOR RECEPTOR Meaning and Definition

1. Ciliary neurotrophic factor receptor (CNTFR) is a transmembrane protein that plays a key role in the signaling pathway of ciliary neurotrophic factor (CNTF), a cytokine involved in neural cell development and survival. The CNTFR protein is primarily found in the nervous system and is abundantly expressed in neurons.

   The CNTFR protein is composed of multiple subunits, including the CNTFRα subunit and two additional subunits, gp130 and LIFRβ. These subunits form a receptor complex necessary for CNTF binding and subsequent activation of downstream signaling cascades. The binding of CNTF to the CNTFRα subunit triggers the recruitment of gp130 and LIFRβ, resulting in the assembly of a functional receptor complex that initiates intracellular signaling.

   Upon activation, the CNTFR complex activates various downstream signaling pathways, such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. This signaling cascade regulates gene expression, cellular differentiation, and survival in neurons. The activation of CNTFR also promotes the production of neurotrophic factors, which enhance the survival and functionality of nerve cells.

   Mutations or dysregulation of CNTFR can lead to abnormal neural development and function, potentially resulting in neurodevelopmental disorders or neurodegenerative diseases. Researchers are actively studying the role of CNTFR and its signaling pathways in various neurological disorders, with the aim of developing therapeutic strategies targeting this receptor complex for the treatment of neurodegenerative diseases and nerve injury.

Common Misspellings for CILIARY NEUROTROPHIC FACTOR RECEPTOR

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