CHERUBISM Meaning and
Definition
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Cherubism is a rare genetic disorder characterized by abnormal, excessive growth of the jaw and cheekbones, resulting in a distinct facial appearance. The term derives from the resemblance of affected individuals to cherubs, due to the round and puffy cheeks. This condition typically becomes prominent during early childhood and progressively worsens until puberty, after which it may stabilize or regress.
The exact cause of Cherubism is linked to mutations in the SH3BP2 gene, suggesting an autosomal dominant inheritance pattern. However, not all individuals with the mutation will display symptoms of the disorder. While the precise mechanisms remain unclear, it is believed that these genetic alterations cause an uncontrolled growth of the bone cells, leading to the characteristic swelling and deformity of the facial bones.
Common signs of Cherubism include swollen cheeks, an enlarged lower jaw, and dental abnormalities like delayed tooth eruption or crowding. The affected facial bones may be fragile and prone to fractures. In some cases, the condition can also affect other areas of the skeleton, such as the long bones or the spine.
Diagnosis of Cherubism involves a combination of clinical evaluation, imaging studies (such as X-rays or CT scans), and genetic testing. Treatment options for Cherubism are limited, with management focused on addressing complications, managing symptoms, and providing psychological support for affected individuals and their families. Surgical intervention may be considered in severe cases to improve facial aesthetics and functional concerns.
Overall, Cherubism is a rare genetic disorder characterized by progressive facial bone abnormalities, predominantly affecting the jaw and cheekbones, resulting in a cherub-like appearance.
Common Misspellings for CHERUBISM
- cherubims
- cherubis
- cherubs
- xherubism
- vherubism
- fherubism
- dherubism
- cgerubism
- cberubism
- cnerubism
- cjerubism
- cuerubism
- cyerubism
- chwrubism
- chsrubism
- chdrubism
- chrrubism
- ch4rubism
- ch3rubism
- cheeubism
Etymology of CHERUBISM
The word "Cherubism" originates from the Hebrew word "keruv", which means "cherub". Cherubs are depicted as plump, chubby-cheeked angels in religious iconography. The term "Cherubism" was coined due to the characteristic facial appearance associated with the condition. Individuals with Cherubism tend to develop excessive swelling of the lower part of the face, resulting in round, cherub-like cheeks.
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