CFTR PROTEIN Meaning and
Definition
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The CFTR protein, also known as the Cystic Fibrosis Transmembrane Conductance Regulator protein, is a crucial transmembrane protein involved in maintaining the balance of ions in the body's cells, particularly in the respiratory and gastrointestinal systems.
The CFTR protein belongs to the ABC transporter family and is primarily expressed in the epithelial cells lining various organs, such as the lungs, pancreas, liver, and intestines. Its main function is to regulate the movement of chloride ions in and out of cells.
In individuals with cystic fibrosis (CF), a genetic disorder, mutations occur in the CFTR gene, leading to a dysfunctional CFTR protein. This protein malfunction results in the inadequate transport of chloride ions, which affects the balance of salt and water in the body's cells. As a consequence, thick and sticky mucus accumulates in the affected organs, leading to various symptoms and complications associated with CF.
The CFTR protein consists of several functional domains, including a nucleotide-binding domain (NBD1 and NBD2), which bind and hydrolyze ATP to facilitate chloride ion transport across the cell membrane. It also contains a regulatory domain (R domain) that interacts with various cellular signaling molecules to regulate CFTR activity.
Understanding the structure and function of the CFTR protein is crucial for the development of effective treatments for cystic fibrosis. Researchers have been exploring approaches like gene therapies, pharmacological modulators, and protein correctors to restore the function of CFTR proteins in CF patients and alleviate the associated symptoms.
Common Misspellings for CFTR PROTEIN
- xftr protein
- vftr protein
- fftr protein
- dftr protein
- cdtr protein
- cctr protein
- cvtr protein
- cgtr protein
- cttr protein
- crtr protein
- cfrr protein
- cffr protein
- cfgr protein
- cfyr protein
- cf6r protein
- cf5r protein
- cfte protein
- cftd protein
- cftf protein
- cftt protein
Etymology of CFTR PROTEIN
The etymology of the term "CFTR protein" can be understood by breaking down its components.
1. CFTR: CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator. This abbreviation is derived from the name of the disease it is associated with, cystic fibrosis (CF), and its function as a regulator of conductance across cell membranes.
2. Protein: The term "protein" originates from the Greek word "proteios", which means "of primary importance" or "first quality". It was coined by Swedish chemist Jöns Jacob Berzelius in 1838 to describe the organic compounds essential for the structure and function of living organisms.
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