CAMKII Meaning and
Definition
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CAMKII is an abbreviation for Calcium/Calmodulin-Dependent Protein Kinase II, which refers to a multifunctional enzyme that plays a crucial role in various cellular and molecular processes. It is a serine/threonine protein kinase that is primarily found in the brain and is widely distributed in the central nervous system.
The enzyme derives its name from its dependency on the binding of calcium and calmodulin for activation. Upon the binding of calcium and calmodulin, CAMKII undergoes autophosphorylation, resulting in its prolonged activation even after calcium levels return to baseline. This unique feature distinguishes CAMKII from other kinases and makes it a vital regulator in long-term potentiation, a process involved in synaptic plasticity and memory formation.
CAMKII is involved in intracellular signaling cascades and has been implicated in various cellular functions, including neuronal plasticity, gene expression, cell differentiation, and cell cycle regulation. Its versatile functions have led to its association with numerous pathophysiological conditions, including neurodegenerative diseases, psychiatric disorders, epilepsy, and cancer.
The study of CAMKII has contributed significantly to our understanding of cellular signaling mechanisms and their impact on diverse biological processes. Its remarkable involvement in brain function and disease pathogenesis has made it a target of interest for developing therapeutic interventions aimed at modulating cellular activity and potentially treating several neurological and psychiatric disorders.
Common Misspellings for CAMKII
- kAMKII
- gAMKII
- aAMKII
- bAMKII
- CiMKII
- CeMKII
- CcMKII
- CAeKII
- CAoKII
- CAlKII
- CAMcII
- CAMKyI
- CAMKaI
- CAMKhI
- CAMKIy
- CAMKIm
- CAMKIh
- c amkii
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