How Do You Spell CALCITONIN GENE RELATED PEPTIDE II?
Pronunciation: [kˈalsɪtˌɒnɪn d͡ʒˈiːn ɹɪlˈe͡ɪtɪd pˈɛpta͡ɪd ɹˌə͡ʊmən tˈuː] (IPA) 
Pronunciation: [kˈalsɪtˌɒnɪn d͡ʒˈiːn ɹɪlˈe͡ɪtɪd pˈɛpta͡ɪd ɹˌə͡ʊmən tˈuː] (IPA)
Calcitonin gene-related peptide II (CGRP II) is a neuropeptide that belongs to the calcitonin family. It is derived from the calcitonin gene, which is primarily expressed in the peripheral sensory neurons. CGRP II is structurally similar to calcitonin gene-related peptide I (CGRP I), with only a few amino acid differences.
CGRP II is primarily found in the peripheral nervous system, especially in sensory ganglia, where it is involved in regulating pain transmission and modulating vascular tone. It acts as a potent vasodilator, promoting widening of blood vessels, and is thought to play a crucial role in the regulation of blood flow.
Furthermore, CGRP II is involved in mediating neurogenic inflammation, which is inflammation mediated by the release of neuropeptides from sensory neurons. It acts by increasing the permeability of blood vessels and promoting the recruitment of immune cells to the site of inflammation.
Recent research has also indicated that CGRP II may have a role in migraine pathogenesis. Elevated levels of CGRP II have been observed in the blood during migraine attacks, suggesting its involvement in the development and progression of migraines.
In summary, calcitonin gene-related peptide II is a neuropeptide that modulates pain transmission, regulates vascular tone, mediates neurogenic inflammation, and possibly contributes to the pathogenesis of migraines. Its role in various physiological and pathological processes makes it an intriguing target for therapeutic interventions.
